LTC Lu Makinde presents at ANS
Biomaterials & Interfaces Lab
Dr. Nathan Gallant established the Biomaterials & Interfaces Lab at USF to develop functional surfaces and coatings for biomedical applications. Our interdisciplinary research primarily lies at the intersection of biomaterials, mechanobiology, and cell adhesion. We analyze the mechanical and biochemical interactions between cells and their microenvironment in order to design instructive biomaterials to control cell behavior through the design of functional bio-interfaces. Our core foci are quantitative cell adhesion strengthening, engineered gradient and patterned biomaterials, substrate mechanics, and mechanobiology framed in an engineering perspective. These strategies have been applied to research projects spanning fundamental discovery (cell shape regulation of adhesion strength) to translational solutions (polymer coatings for implanted devices).
New Research Directions
Mixed field radiation dosimetry
Current methods for measuring radiation from both neutrons and gamma rays are not currently adequate for a mass-casualty scenario as signs and symptoms can be misleading and laboratory tests are time-consuming and expensive. We are investigating a single material that may have unique interactions in mixed fields such that the effects and doses can be separated for accurate field identification and dosimetry.
Enhanced thermal conductivity in cryopreservation
Incorporating thermally conductive, biocompatible nanomaterials into cryoprotective agents (CPAs) to enhance heat transfer improves cooling and warming rates. Improved thermal conductivity is essential for realizing the full potential of vitrification to preserve CPA-sensitive cells and enable scale up to large volumes of cells.
